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RNA Silencing in Surgical Disease
Jyoti Arya, MD;
John Y. Cha, MD;
Anirban Banerjee, PhD;
Alden H. Harken, MD
Arch Surg. 2003;138:1145-1147.
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INTRODUCTION
Each of our cells contains a complete copy of the genes required to create a whole organism. Thus, it was possible to clone Dolly from a single sheep epidermal cell, and we should be able to reconstruct a dinosaur from the genetic material buried in the mud of "Jurassic Park." However, it is hard to believe that by adding water to the $5 worth of chemicals in a human, it is possible to create a human being. Although 30 000 instructions, or genes, sounds like a lot, the creation of a hand or a heart or a mind is still a daunting task. Our current genetic code is a lot like the King James Bible—both have evolved. The travails of Moses or Noah were initially "transcribed" by clerics into huge books safely stored in cathedral vaults. . . . [Full Text of this Article]
CLASSICAL DNA-DRIVEN PROTEIN SYNTHESIS
WHAT DO ncRNAS DO?
HOW DOES ncRNA PROTECT THE CELL?
siRNA AMPLIFICATION
SURGICAL GENE KNOCKOUT OWNER'S MANUAL
RNA SILENCING AS THERAPY
From the Departments of Surgery, University of California–San Francisco, East Bay, Oakland, and University of Colorado Hospital, Denver.
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RNA Silencing in Surgical Disease—Invited Critique
Stephen F. Lowry
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