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Extracolonic Manifestations of Familial Adenomatous Polyposis After Proctocolectomy—Invited Critique
Thomas Attard, MD;
Henry Lynch, MD
Arch Surg. 2005;140:164.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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The genetics of FAP can be a nightmare.1
An enduring concern in the treatment of FAP is the course of the disease after colectomy; its rarity and its clinical heterogeneity limit our understanding of extracolonic neoplastic manifestations, especially if these develop at a relatively advanced age. Tulchinsky et al report their experience with several extraintestinal complications of FAP; they have also highlighted several factors that influence their choice of prophylactic surgery, including the risk of rectal tumor development and desmoid tumors. Further comment is merited about the correlation between the phenotype: the clinical behavior of FAP, and the mutation in the adematous polyposis coli (APC) gene on chromosome 5q21; such a mutation is detectable in about 80% of the patients with FAP. Although its testing is increasingly more accessible, there is a compelling need for genetic counseling.2
The molecular pathophysiology of phenotype-genotype . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED ARTICLE
Extracolonic Manifestations of Familial Adenomatous Polyposis After Proctocolectomy
Hagit Tulchinsky, Andrei Keidar, Hana Strul, Gideon Goldman, Joseph M. Klausner, and Micha Rabau
Arch Surg. 2005;140(2):159-163.
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