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Jeffrey B. Matthews, MD

Arch Surg. 2005;140:410.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Pasupathy and Homer-Vanniasinkam provide a brief overview of IP, systematically surveying the surgical implications of this phenomenon in a variety of organs. A recurrent theme is the disconnect between the extensive experimental evidence indicating the potential to exploit this phenomenon to improve outcome after ischemic stress and the dearth of actual human data demonstrating clinical benefit. This disconnect is obviously not limited to the field of IP. One of the major motivating factors behind the new "roadmap," outlined by Elias Zerhouni, MD, director of the National Institutes of Health, is the need to overcome the so-called translational block that prevents basic research advances from moving into everyday clinical practice. Despite nearly 2 decades of research into IP, the upstream events that trigger the adaptive response to sublethal ischemia, and the downstream targets that mediate protection, remain only partially understood. This review does not delve deeply into . . . [Full Text of this Article]

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Surgical Implications of Ischemic Preconditioning
Shanker Pasupathy and Shervanthi Homer-Vanniasinkam
Arch Surg. 2005;140(4):405-409.
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