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Russell G. Postier, MD

Arch Surg. 2006;141:1100.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Cunningham et al have described the results of IHC staining for the MKK4 gene in a group of 124 patients who underwent resection of GA during a 12-year period. The authors have long-term follow-up data for 114 of these patients that represent the basis for the article. They have shown significantly worse survival in patients with MKK4-negative tumors. They believe that MKK4 acts as a tumor suppressor gene and that its mutation results in a more aggressive tumor with a negative effect on survival. MKK4 may prove to be an important predictor of survival in patients with GA, but serious limitations of this study render that conclusion premature. Only 9 of 114 patients had MKK4-negative tumors and form the basis for a broad conclusion backed by complicated statistical analysis on these few tumors. More of the patients with MKK4-positive tumors had more advanced . . . [Full Text of this Article]

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