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Effects of Decreased Preoperative Endotoxin Core Antibody Levels on Long-term Mortality After Coronary Artery Bypass Graft Surgery—Invited Critique
Irving L. Kron, MD
Arch Surg. 2006;141:642.
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Moretti and colleagues from Duke University have demonstrated that preoperative levels of EndoCAb are associated with increased long-term mortality after CABG surgery using CPB. This is truly a unique finding and worthy of further discussion. Essentially, this finding implies that increased EndoCAb levels carry increased short- and long-term risks after CABG surgery. Although the findings are statistically significant, I’m not sure I understand the logic of this finding. We don't know why the patients died in either subgroup, so it is difficult to explain the increased long-term mortality based on potential increases in EndoCAb levels. In addition, it does not seem that the authors have excluded 30- or 60-day mortality from the analysis.
The authors explained in their discussion their thoughts about this association. They stated that low EndoCAb levels may potentially be a marker for increased operative risk. Although they used the Parsonnet additive risk . . . [Full Text of this Article]
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Effects of Decreased Preoperative Endotoxin Core Antibody Levels on Long-term Mortality After Coronary Artery Bypass Graft Surgery
Eugene W. Moretti, Mark F. Newman, Lawrence H. Muhlbaier, David Whellan, Rebecca P. Petersen, Daniel Rossignol, Charles B. McCants, Jr, Barbara Phillips-Bute, and Elliott Bennett-Guerrero
Arch Surg. 2006;141(7):637-641.
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