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Arthur E. Baue, MD

Arch Surg. 2007;142(1):89-93.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

This is a review of 2 topics: (1) mediators and activities whose levels or performances indicate or predict an unfavorable outcome and (2) biologic activities (puzzles) in which too much of a substance (mediator) is bad but too little is even worse and vice versa (the just right physiological principle). Mediators or activities may predict disaster but, by and large, knowing this does not help us take better care of patients. They certainly contribute to our understanding of disease. Biologic puzzles may help us better understand clinical situations. Knowledge of such studies should help us to better understand the processes of injury, illness, inflammation, and sepsis and to devise further studies to improve the care of our patients.

The explosion of knowledge about injury, inflammation, and infection identified many mediators, biologic functions, and activities involved in these processes. The complexities and interrelationships of these mediators make . . . [Full Text of this Article]

HARBINGERS OF DISASTER OR ETIOLOGIES OF DOOM—CRITICAL EVENT SCORING OR MEDIATOR LEVELS THAT PREDICT DISASTER (OR MOF OR ARDS)


BIOLOGIC CONUNDRUMS (PUZZLES OR AMBIGUITIES) WITH SERIOUS INFLAMMATION DUE TO ILLNESS AND INJURY

AUTHOR INFORMATION


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