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Silvia Nunes Szente Fonseca, MD, MPH; Sônia Regina Melon Kunzle, RN; Maria José Junqueira, RN; Renata Teodoro Nascimento, MD; José Ivan de Andrade, MD, PhD; Anna Sara Shafferman Levin, MD, PhD

Arch Surg. 2007;142(6):577.

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We read with interest the comments by Dr Schmidt and feel that there are some points to consider. Our study was not aimed to prove that 1-dose prophylaxis is as effective as a 24-hour regimen. In fact, the objectives of this study were to demonstrate how to implement a 1-dose regimen in a general hospital. The fact that 1-dose prophylaxis reduces surgical site infections as effectively as a 24-hour regimen had already been demonstrated in innumerous trials, such as the one published by Scher.¹ One-dose prophylaxis is a widely approved recommendation published in several guidelines,² some of them cited in our article.

Many hospitals have tried to implement appropriate prophylaxis programs with different success rates.³ There are . . . [Full Text of this Article]

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