JAMA
Cognitive and Cardiac Outcomes 5 Years After Off-Pump vs On-Pump Coronary Artery Bypass Graft Surgery
Diederik van Dijk, MD, PhD; Monique Spoor, MS; Ron Hijman, PhD; Hendrik M. Nathoe, MD, PhD; Cornelius Borst, MD, PhD; Erik W. L. Jansen, MD, PhD; Diederick E. Grobbee, MD, PhD; Peter P. T. de Jaegere, MD, PhD; Cor J. Kalkman, MD, PhD; for the Octopus Study Group
Context: Conventional coronary artery bypass graft surgery with use of cardiopulmonary bypass (on-pump CABG) is associated with excellent long-term cardiac outcomes but also with a high incidence of cognitive decline. The effect of avoiding cardiopulmonary bypass (off-pump CABG) on long-term cognitive and cardiac outcomes is unknown.
Objective: To compare the effect of off-pump CABG and on-pump CABG surgery on long-term cognitive and cardiac outcomes.
Design, Setting, and Participants: The Octopus Study, a multicenter randomized controlled trial . . . [Full Text of this Article]