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Arch Surg. 2007;142(7):688.

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Answer: Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common malignancy among white persons, but its occurrence in the nipple-areola complex is exceedingly rare, having first been described in the literature in 1893¹ and since reported 16 times. The overall incidence of BCC in North America is approximately 10% per year, with an overall lifetime risk of 30%.² Exposure to UV light is felt to be the main causative factor in the development of BCC, along with family history of skin cancer, low intake of certain vitamins, and exposure to ionizing radiation and various chemicals such as arsenic.² Approximately 80% of BCCs are found on the head or neck, and the most common morphology is a pearly ulcerative lesion with a raised, indurated border ("rodent ulcer"). Basal cell carcinoma tends to be an indolent, slow-growing tumor that may spread to local tissue but has low metastatic rates varying from 0.0028% to 0.55%.² . . . [Full Text of this Article]

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Arch Surg. 2007;142(7):687.
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