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Arch Surg. 2007;142(9):902.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Answer: Serrated Adenomatous Polyposis

Over the last 15 years, better understanding of the relationship between colorectal polyps and colorectal cancer has challenged the traditional neoplastic pathway from adenoma to carcinoma.¹ Historically, clinicians have considered hyperplastic polyps to have no malignant potential. However, in 1990, pathologists Longacre and Fenoglio-Preiser² described mixed hyperplastic adenomatous polyps that demonstrated serrated glands with varying degrees of dysplasia. These so-called serrated adenomas were identified throughout the colon, sometimes in association with hyperplastic polyposis and frank carcinoma. Most serrated adenomas are in the sigmoid (20%) and rectum (33%), with a prevalence of 1% to 7% at colonoscopy.^3-4 Studies of their morphology and classification have led investigators to propose a "serrated neoplasia pathway."^5-6

Serrated adenomatous polyposis was described by Torlakovic and Snover⁷ in patients with putative hyperplastic polyposis with or without carcinoma. Endoscopic examination revealed sheets of colorectal polyps consistent with familial adenomatous polyposis (FAP), but pathologic examination showed apparent hyperplasia and . . . [Full Text of this Article]

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Arch Surg. 2007;142(9):901.
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