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Tetsuji Fujita, MD

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In their interesting study comparing circulating B-type natriuretic peptide (BNP) concentrations in 13 patients with septic shock with those in 18 patients with sepsis but without shock and 18 age-matched healthy controls, Kandil and colleagues¹ found that BNP elevation was correlated with severity of sepsis. They concluded that BNP measurement is useful for predicting the outcomes of patients with septic shock. The mean BNP concentrations, which were measured with a commercially available single-use fluorescence immunoassay, were 849.4 pg/mL in patients with septic shock, 120.0 pg/mL in those having early sepsis without shock, and 100.0 pg/mL in healthy controls. It appears that the method for determining circulating BNP levels has not been standardized. In a recent study that evaluated the validity of BNP as a predictor of postoperative cardiac events in patients undergoing major noncardiac operations, there was about a 25-fold increase in cardiac events in those with . . . [Full Text of this Article]

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B-Type Natriuretic Peptide: A Biomarker for the Diagnosis and Risk Stratification of Patients With Septic Shock
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