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Significance of Circulating B-Type Natriuretic Peptide in Sepsis—Reply
Emad Kandil, MD;
Martin H. Bluth, MD, PhD
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In reply
Dr Fujita raises important issues. Natriuretic peptides emerged during recent years as potent prognostic markers in patients with heart failure and acute myocardial infarction. In addition, natriuretic peptides show strong predictive value in patients with pulmonary embolism, sepsis, renal failure, and shock. Our recently published study tests the prognostic information of BNP in a cohort of critically ill patients with septic shock. We have demonstrated that BNP concentrations are significantly increased in patients with septic shock and may play an important role in risk stratification in these patients independent of congestive heart failure. It could very well be that changes or the rate of elevation in BNP concentrations may be an important component of disease prognostication in sepsis. Similar concerns were raised when prostate-specific antigen was being investigated as a marker for prostate cancer. Numerous approaches were deemed of value . . . [Full Text of this Article]
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RELATED ARTICLE
B-Type Natriuretic Peptide: A Biomarker for the Diagnosis and Risk Stratification of Patients With Septic Shock
Emad Kandil, Joshua Burack, Ahmed Sawas, Haidy Bibawy, Alex Schwartzman, Michael E. Zenilman, and Martin H. Bluth
Arch Surg. 2008;143(3):242-246.
ABSTRACT
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RELATED LETTER
Significance of Circulating B-Type Natriuretic Peptide in Sepsis
Tetsuji Fujita
Arch Surg. 2008;143(10):1021-1022.
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