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Severe Acute Gastrointestinal Graft-vs-Host Disease—Invited Critique
Charles R. Scoggins, MD, MBA
Arch Surg. 2008;143(11):1046.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Irani and colleagues address a difficult problem: how to surgically treat a patient who has had a stem cell transplant and is suspected of having GI manifestations of GVHD. This complication poses a serious risk to the patient's life, as most patients will ultimately die, although not of surgically correctable reasons. Most commonly, surgeons are asked to see patients with GI GVHD because of abdominal pain, distention, and bleeding. These are challenging patients, as they are immunosuppressed, thus the signs of peritonitis may potentially be masked.
The main criticism of this study is that we don't know how many of the patients may have had physical examination findings for which a surgeon would have recommended exploration, but owing to their comorbidities and generally debilitated condition due to the stem cell transplant, they were not considered good surgical candidates. In other words, if they were in . . . [Full Text of this Article] AUTHOR INFORMATION
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Jennifer L. Irani, Corey S. Cutler, Edward E. Whang, Thomas E. Clancy, Sara Russell, Richard S. Swanson, Stanley W. Ashley, Michael J. Zinner, and Chandrajit P. Raut
Arch Surg. 2008;143(11):1041-1045.
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