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Arch Surg. 2008;143(12):1234.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Answer: Celiac Disease

Celiac disease is a common immunological disorder resulting from inflammatory injury to the mucosa of the small intestine secondary to an inappropriate T-cell–mediated response to the presence of gluten hordeins and secalins in the diet of genetically susceptible individuals, almost all of whom share the major histocompatibility complex class II HLA-DQ2 or HLA-DQ8 haplotype. Presentation in adults is usually nonacute, with symptoms lasting many months to years, and may include nonspecific abdominal pains, diarrhea, vomiting, malnutrition, steatorrhea, and extraintestinal manifestations such as peripheral neuropathy, ataxia, and seizures. Intussusception can present acutely; however, it is usually subacute or chronic owing to the muscular hypotonia of the small intestine. Transient asymptomatic small-bowel intussusception in celiac disease is well reported¹ and can be seen in up to 20% of patients.² Adults with non-lead-point intussusception should undergo a biopsy of the duodenum to rule out celiac disease, with duodenal biopsy specimens obtained from the . . . [Full Text of this Article]

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