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Timothy J. Price, MBBS, FRACP; Amanda Townsend, MBBS

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with interest the review of yttrium 90 microsphere selective internal radiation treatment (SIRT) by Gulec et al.¹ The authors discussed the administration technique, benefits, and complications of SIRT. They note the importance of combining SIRT with chemotherapy, in particular 5-fluorouracil (5-FU) as a radiosensitizer, and recommend chemotherapy be given in "close temporal proximity to the radiation." In conclusion they state that SIRT has a potential role in the multimodality treatment of unresectable colorectal cancer metastases, but further data are required to determine the optimal strategy of multimodality treatment. We have recently reviewed the topic of combining chemotherapy and SIRT and found there is a lack of guidance in the literature on the appropriate timing of chemotherapy administration in relation to SIRT. In the most recent report, SIRT was administered in combination with 5-FU and oxaliplatin.² There is, however, a theoretical . . . [Full Text of this Article]

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