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Image of the Month—Quiz Case
Timothy L. Frankel, MD;
Paul G. Gauger, MD
Arch Surg. 2009;144(4):377.
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INTRODUCTION
A 51-year-old man with multiple endocrine neoplasia type I (MEN I) complained of indigestion, diarrhea, abdominal pain, and fatigue. Previous manifestations of MEN I had included hyperprolactinemia, hyperparathyroidism, pancreatic endocrine tumors, and hypergastrinemia. His symptoms were refractory to high doses of a proton pump inhibitor (oral omeprazole [Prilosec], 80 mg, twice daily). Previous operations included subtotal parathyroidectomy and 3 intra-abdominal neuroendocrine tumor resections (distal pancreatectomy, duodenotomy, and submucosal tumor resection and enucleation of multiple neuroendocrine tumors from the head and neck of the pancreas). Physical examination revealed only previous abdominal scars and slight epigastric tenderness. While the patient was under observation and coincident with worsening symptoms, fasting unstimulated serum gastrin levels increased to 2043 pg/mL (normal range, 25-110 pg/mL) (to convert to picomoles per liter, multiply by 0.481). The human pancreatic polypeptide level was elevated to 439 ng/mL (normal level, <290 ng/mL). . . . [Full Text of this Article]
What Is the Diagnosis?
Author Affiliations: Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor.
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Image of the Month—Diagnosis
Arch Surg. 2009;144(4):378.
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