Primary hyperparathyroidism in patients with multiple endocrine neoplasia syndromes. Surgical experience
J. A. van Heerden, R. B. Kent 3rd, G. W. Sizemore, C. S. Grant and W. H. ReMine
Forty-five patients with biochemically documented primary
hyperparathyroidism as part of multiple endocrine neoplasia syndrome types
1 or 2 were surgically treated from 1960 through 1980. Hyperplasia occurred
in 69% of the patients, single adenoma in 27%, and double adenomas in 4%.
All but two patients with hyperplasia underwent subtotal parathyroidectomy.
In this group, the cure rate was 93% and the incidence of permanent
postoperative hypoparathyroidism 23%. In the adenoma group, treatment
included excision of the adenoma and biopsy of at least one other gland.
The cure rate was 76%, with no postoperative hypoparathyroidism. Analysis
of patients with persistent hyperparathyroidism suggested that failure to
recognize multiple gland disease was the principal cause of postoperative
hypercalcemia. In view of the high incidence of hypocalcemia after subtotal
parathyroidectomy, approximately 500 mg of tissue should be cryopreserved
to allow transplantation should hypocalcemia ensue postoperatively.
