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Xin Chu, PhD; Robert Erdman, BS; Meghan Susek; Heather Gerst, DO; Kimberly Derr, BS; Mouna Al-Agha, MD; G. Craig Wood, MS; Christina Hartman, BS; Stephanie Yeager, BS; Mary Ann Blosky, BS; Wanda Krum, BS; Walter F. Stewart, PhD; David Carey, PhD; Peter Benotti, MD; Christopher D. Still, DO; Glenn S. Gerhard, MD

Arch Surg. 2008;143(3):235-240.

Objective  To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations.

Design  Retrospective analysis of genotype and clinical data.

Setting  Large rural tertiary care health system.

Patients  A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania.

Results  The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups.

Conclusion  Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.

Author Affiliations: The Geisinger Clinic, Danville, Pennsylvania.

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