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Eddie L. Hoover, MD

Arch Surg. 2008;143(3):246.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Kandil and colleagues purport a role for BNP level as a useful marker of ventricular function and mortality in sepsis. There were no demographic data provided for the groups, specifically age and the underlying disease. Also, the absence of any BNP data between days 1 and 21 precludes potential useful information about BNP activity in response to therapy. These investigators state that patients without renal and heart failure may benefit from measurement of BNP levels but do not present any supporting data, only concepts. They also state that BNP level determination may help with risk stratification, which is suspect because there was no significant difference between the control subjects and patients with early sepsis (100 ± 9.4 vs 120 ± 11.2 pg/mL). They further stated that BNP level may serve as "a valuable measure for determining reduced left ventricular function in patients with septic shock"; again, with no supporting data. . . . [Full Text of this Article]

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B-Type Natriuretic Peptide: A Biomarker for the Diagnosis and Risk Stratification of Patients With Septic Shock
Emad Kandil, Joshua Burack, Ahmed Sawas, Haidy Bibawy, Alex Schwartzman, Michael E. Zenilman, and Martin H. Bluth
Arch Surg. 2008;143(3):242-246.
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