• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Renal Diseases  • Renal Diseases, Other  • Transplantation  • Kidney Transplantation  • Prognosis/ Outcomes  • Infectious Diseases  • Alert me on articles by topic  Social Bookmarking   What's this?

Long-term Outcomes and Risk Factors for Graft Loss

Jayme E. Locke, MD, MPH; Robert A. Montgomery, MD, DPhil; Daniel S. Warren, PhD; Aruna Subramanian, MD; Dorry L. Segev, MD

Arch Surg. 2009;144(1):83-86.

ABSTRACT
In the highly active antiretroviral therapy era of improved survival for patients living with human immunodeficiency virus (HIV), chronic kidney disease now accounts for more than 10% of HIV-related deaths. The role of kidney transplant among HIV-positive patients with end-stage renal disease is under consideration, but concerns remain regarding allocation of kidneys to these patients when long-term benefit has not been firmly established. We evaluated 39 501 patients undergoing a renal transplant between January 1, 2004, and June 30, 2006, identified through the United Network for Organ Sharing national registry and found that, although long-term allograft survival is lower among HIV-positive recipients, controllable risk factors may explain this disparity. With proper donor selection and transplant recipient management, including the avoidance of prolonged cold ischemic time, use of living donors, and determination of optimal immunosuppression dosing before transplant, long-term graft survival comparable to that in HIV-negative patients can be achieved.

Author Affiliations: Division of Transplantation, Department of Surgery (Drs Locke, Montgomery, Warren, and Segev), and Division of Infectious Diseases, Department of Medicine (Dr Subramanian), Johns Hopkins Medical Institutions, Baltimore, Maryland.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

HIV infection and renal transplantation
Mazuecos et al.
Nephrol Dial Transplant 2011;26:1401-1407.
ABSTRACT | FULL TEXT  

Kidney Transplantation and HIV: Does Recipient Privacy Outweigh the Donor's Right to Information?
Formica et al.
CJASN 2010;5:924-928.
ABSTRACT | FULL TEXT  

Kidney Transplant in HIV-Infected Patients
AIDS Clin Care 2009;2009:1-1.
FULL TEXT