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In the Presence of Immunosuppression

Gerald P. Murphy, MD; Edwin A. Mirand, PhD; Johannes H. Groenewald, MD; Gerald M. Kenny, MD

AMA Arch Surg. 1970;100(1):20-23.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Erythropoietin (ESF) is a hormone of renal origin active in the regulation of red cell production.¹ Various factors or stimuli are known to result in ESF release. These include bleeding,² hypoxic hypoxia exposure,³ exogenous androgen administration,⁴ or cobalt chloride treatment.⁵ Autotransplanted canine kidneys can respond to various erythropoietic stimuli as can normal intact kidneys.⁶

The present experiments were conducted to test further the response of animals with renal allografts, with and without various forms of immunosuppression to various erythropoietic stimuli.

Materials and Methods

Adult male and female mongrel dogs, in healthy condition, underwent bilateral nephrectomy and received a kidney from an unrelated donor. Postoperatively, animals with functioning grafts were either untreated or given yeast respiratory extract (PCO),⁷ 50 mg/kg every other day; azathioprine (Imuran), 5 mg/kg daily, or azathioprine and PCO in similar but combined fashion. Routine biochemical and hematological preoperative and postoperative . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

From the departments of urology and experimental surgery, Roswell Park Memorial Institute, and Regional Kidney Center, New York State Kidney Institute, New York State Department of Health, and the School of Medicine, State University of New York, Buffalo.

Footnotes
Submitted for publication Aug 29, 1969.

Reprint requests to Associate Director of Clinical Affairs, Roswell Park Memorial Institute, 666 Elm St, Buffalo 14203 (Dr. Murphy).

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