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Sten Tibblin, MD; Nils G. Kock, MD; Worthington G. Schenk, Jr., MD

AMA Arch Surg. 1970;100(1):84-89.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Glucagon, a substance originally thought exclusively to play a part in carbohydrate metabolism, has during recent years been found to possess several other important properties. Among them are influence on tubular reabsorption of electrolytes,¹ on adrenal medullary secretion,² on calcium metabolism,³ on gastric secretion,⁴ and on gastrointestinal motility.^5,6

During the last decade, cardiovascular effects have been added to the increasing list of glucagon characteristics. Shoemaker et al⁷ reported an increase in liver blood flow after glucagon administration. They used the sulfobromophthalein (Bromosulphthalein [BSP]) sodium technique to study the hepatic blood flow. The flow increase paralleled the blood glucose rise. Merrill et al⁸ demonstrated a vasodilatory effect of glucagon on the splanchnic vascular bed in perfusion experiments. Parmley et al⁹ reported an inotropic and chronotropic effect on cardiac activity following glucagon injection in man. In a recent publication, Kock et al,¹⁰ using . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

From the Department of Surgery, State University of New York at Buffalo and the Surgical Research Laboratory, E. J. Meyer Memorial Hospital, Buffalo. Drs. Tibblin and Kock are Buswell Fellows in surgical research, State University of New York at Buffalo.

Footnotes
Submitted for publication July 10, 1969.

Reprint requests to State University of New York at Buffalo, E. J. Meyer Memorial Hospital, Buffalo, NY 14215.

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