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Leonard L. Bailey, MD; Wilfred M. Huse, MD; Ellsworth E. Wareham, MD; Robert J. Wagner, MD; Weldon B. Jolley, PhD; Louis L. Smith, MD

AMA Arch Surg. 1970;100(2):129-131.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Modification of graft antigenicity poses an attractive alternative to the complex problems arising from host immunosuppression. Preliminary reports^1-5 suggest that treatment of simple organs such as skin with soluble RNA prior to transplantation prolongs graft survival without the addition of immunosuppressive agents. In seeking to apply this principle to more complex organs such as the heart, it becomes necessary to develop some means for isolated organ support during this type of treatment. Techniques^6-10 utilizing hypothermia or hyperbaric oxygenation or both are unsatisfactory for organ pretreatment. Previously described perfusion techniques, as summarized by Hardy et al¹¹ are traumatic and hazardous to tissue preservation. It is the purpose of this communication to describe a simplified perfusion preparation developed and used in our laboratory for pretreatment and preservation of canine donor hearts for transplantation. This technique has proved to be rapid and inexpensive as well as atraumatic to the heart.

Method . . . [Full Text PDF of this Article]

Author Affiliations
Loma Linda, Calif

From the Surgical Research Laboratory, Department of Surgery, Loma Linda University School of Medicine, Loma Linda, Calif.

Footnotes
Accepted for publication Oct 21, 1969.

Reprint requests to Surgical Research Laboratory, Department of Surgery, Loma Linda University School of Medicine, Loma Linda, Calif 92354 (Dr. Smith).

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