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Stress UlcersA Clinical and Experimental Study Showing the Roles of Mucosal Susceptibility and Hypersecretion
Harold O. Douglass, Jr., MD;
Harry H. LeVeen, MD
AMA Arch Surg. 1970;100(2):178-181.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Upper-gastrointestinal tract bleeding or perforation, occurring during convalescence from operation or major illness, is frequently lethal. Incidence and mortality rise when the convalescence is stormy. Like steroid ulcers, stress ulcers occur without premonitory symptoms. The first sign of the stress ulcer is usually upper-gastrointestinal tract bleeding or perforation. Improved salvage from stress ulcers has not paralleled survival from the complications of peptic ulcer disease.
Massive bleeding and perforation are considered indications for surgery in complicated ulcer disease, yet conservative therapy is often recommended for stress ulcers, due to the complexity of the situations in which these ulcers arise. Because bleeding and perforation are life-threatening, proper therapy of stress ulcer is mandatory.
To establish support for clinical observations drawn from a series of 83 stress ulcers, an experimental model, using laboratory animals, was used (details of the experimental technique are described elsewhere).1 The results of the experiment successfully tested the
. . . [Full Text PDF of this Article]
Author Affiliations
Brooklyn
From the Department of Surgery, State University of New York, Downstate Medical Center and Brooklyn Veterans Administration Hospital, Brooklyn.
Footnotes
Submitted for publication Sept 2, 1969.
Reprint requests to Veterans Administration Hospital, 800 Poly Place, Brooklyn NY 11209 (Dr. LeVeen).
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