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Kyoji Sugawara, MD; Jaime Isaza, MD; John R. Curt, MD; Edward R. Woodward, MD

AMA Arch Surg. 1970;100(2):201-204.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In their classic paper published in 1925, Lim et al first demonstrated that distention of the stomach stimulated gastric acid secretion.¹ Almost three decades later the important site for distention was found to be in the pyloric antrum and the mechanism involved was defined as release of the hormone, gastrin.^2,3 The importance of pH and the submucosal parasympathetic plexus have been clearly delineated.^3-5 The purpose of the present study is to relate quantitatively distention of the vagally innervated pyloric antrum to the amount of gastrin released.

Method

Four mongrel dogs, weighing 15 to 18 kg, were prepared with a denervated fundic (Heidenhain) pouch and a vagally innervated antral pouch, using a method previously described.³ The antrum was mapped using the technique of histamine and congo red in order to exclude acid-secreting gastric mucosa from the antral pouch.⁶ The pyloric end of the antrum was brought . . . [Full Text PDF of this Article]

Author Affiliations
Gainesville, Fla

From the Department of Surgery, College of Medicine, University of Florida, Gainesville.

Footnotes
Submitted for publication Sept 10, 1969.

Reprint requests to Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla 32601 (Dr. Woodward).

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