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Bertie J. Wilken, MD, FRCS; William A. Billups, MD; Don G. Hunt, MD; M. Don Turner, PhD; James D. Hardy, MD

AMA Arch Surg. 1970;100(2):205-209.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The method of assaying gastric secretogogues, first described by Ghosh and Schild¹ was modified by Lai² for the assay of gastrin in extracts of gastric antrum and other tissues. This technique was subsequently employed by Sircus³ and by Moore and his colleagues⁴ for the detection of gastrin-like activity in the serum and gastric juice of patients with the Zollinger-Ellison syndrome. The last-named authors reported a high incidence of positive results and emphasized the reliability of the method in the preoperative diagnosis of such patients. Ellison and Wilson,⁵ however, were unable, in several instances, to detect a gastric secretogogue in the serum of patients with proven ulcerogenic tumors of the pancreas.

In establishing the bioassay method for gastrin in our laboratory, it was considered necessary to re-evaluate the factors affecting its sensitivity, range, and reliability, using the now available synthetic gastrin pentapeptide. This report is based . . . [Full Text PDF of this Article]

Author Affiliations
Jackson, Miss

From the Department of Surgery and University Hospital, University of Mississippi Medical Center, Jackson.

Footnotes
Submitted for publication Aug 4, 1969.

Reprint requests to Department of Surgery, University of Mississippi Medical Center, 2500 N State St, Jackson, Miss 39216 (Dr. Hardy).

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