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M. David Tilson, MD

AMA Arch Surg. 1970;100(2):210-211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The mechanisms stimulating compensatory hypertrophy of small intestinal villi after massive resections are unknown but may involve a systemic stimulus.¹ Since ischemic injury has been shown to enhance compensatory renal hypertrophy,² the effect of minimal gut ischemia upon the small bowel epithelium has been investigated.

Methods

Eight female Lewis rats weighing 180 to 220 gm and maintained upon a uniform pellet diet underwent laparotomy under the influence of anesthesia produced by intraperitoneally administered pentobarbital (Nembutal) sodium (2.5 mg/100 gm body weight). The small bowel and cecum were delivered upon a moist sponge. In four animals the four distal vascular arcades of the terminal ileum were cross-clamped for nine minutes with a noncrushing instrument. The small bowel became deeply cyanotic and, upon declamping, the cyanosis of the ileum faded. The gut was replaced in the peritoneal cavity, and the wound was closed in two layers with continuous sutures of . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the Department of Surgery, Yale University School of Medicine, New Haven, Conn.

Footnotes
Submitted for publication Aug 18, 1969.

Reprint requests to Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06510 (Dr. Tilson).

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