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Lee C. Detenbeck, MD; H. Herman Young, MD; Laurentius O. Underdahl, MD

AMA Arch Surg. 1970;100(2):215-219.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

O'Brien and his colleagues¹ recently reported on a review of the world literature on alkaptonuria, ochronosis, and ochronotic arthropathy. In 1859, Boedeker first used the word "alkapton" to describe a reducing substance in the urine of certain patients which had a strong affinity for alkali and caused the urine to become dark brown on standing. The reducing substance was later identified as homogentisic acid by Wolkow and Bauman in 1891. Virchow introduced the term "ochronosis" in 1866 to indicate a clinical disease seen in many young alkaptonuric patients. It was not until 1902 that Albrecht first realized that the three conditions were all various stages of the same disease entity.

Alkaptonuria is an inborn error of metabolism usually inherited as an autosomal recessive gene. There is a wide geographic and racial distribution, but O'Brien and co-workers¹ noted it especially in areas where there is a high incidence of . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn

From the sections of orthopedic surgery (Dr. Young) and medicine (Dr. Underdahl), Mayo Clinic and Mayo Foundation; and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Detenbeck), Rochester.

Footnotes
Submitted for publication Aug 28, 1969.

Reprint requests to Mayo Clinic, Rochester, Minn 55901.

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