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Harvey J. Sugerman, MD; Ralph Hamilton, MD; William P. Graham, III, MD; Peter Randall, MD

AMA Arch Surg. 1970;100(3):240-243.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Certain neoplastic lesions of mucous membranes have been shown to stain after topical application of toluidine blue dye. Richart¹ first reported the use of toluidine blue dye as a vital stain for dysplasia and carcinoma of the uterine cervix. Since then Niebel and Chomet,² Shedd et al,^3,4 Iwano et al,⁵ and Strong et al⁶ have demonstrated its diagnostic value in lesions of the mouth and pharynx, while Collins et al⁷ studied staining of vulvar lesions. Squamous carcinomas, both invasive and in situ, and certain dysplastic lesions of these mucous membranes were stained a blue color by the dye. Staining also occurred in areas of ulceration. Subepidermal extensions of squamous cell carcinomas did not stain but satellite lesions in the mucosa were detected by stain.

Discovery of early primary or recurrent skin cancer is dependent on the arousal of clinical suspicion which leads to biopsy. . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Department of Surgery and the Division of Plastic Surgery, the Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Accepted for publication Oct 18, 1969.

Reprint requests to the Harrison Department of Surgical Research, I. S. Ravdin Institute, Suite 1000, 3400 Spruce St, Philadelphia 19104 (Miss Annette Matkowski).

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