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During Hemodilution With Hydroxyethyl Starch and Dextran 40

Masuhiko Takaori, MD, PhD; Peter Safar, MD; Stephen J. Galla, MD

AMA Arch Surg. 1970;100(3):263-268.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Even though whole blood may be unavailable in the presence of massive hemorrhage, maintenance of an adequate circulating plasma volume is mandatory. Utilizing an experimental model in which hemorrhage was corrected immediately with equal volumes of plasma substitutes, several adaptive mechanisms occurring in dogs during severe, acute hemodilution have been described.^1-3 The observed compensatory increase in cardiac index may have been related partially to hypervolemia. Although several investigators have shown that plasma volume is greater than predicted following the infusion of dextrans of various molecular weights into normovolemic^4-7 or hypovolemic subjects,^8,9 little information is available concerning the origin of the fluid entering the intravascular space, or the changes occurring within the interstitial space.

Because hydroxyethyl starch is more stable and less expensive to produce than dextran 75, it is currently under investigation as a colloidal plasma substitute. Two main purposes distinguish this paper from our previous work: . . . [Full Text PDF of this Article]

Author Affiliations
Pittsburgh

From the Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh. Dr. Takaori is now at the School of Medicine, University of Osaka, Osaka, Japan.

Footnotes
Accepted for publication Oct 21, 1969.

Reprint requests to 1081 Scaife Hall, Pittsburgh 15213 (Dr. Galla).

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