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During Temporary Exclusion of the Liver

Nils G. Kock, MD; Sten Tibblin, MD; Worthington G. Schenk, Jr., MD

AMA Arch Surg. 1970;100(3):280-283.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In recent years cardiovascular effects of glucagon have been demonstrated both in animals and man. Following a single injection of glucagon the hepatic blood flow increased approximately 100%.^1,2 This increase in hepatic blood flow is mainly due to a vasodilatory action of glucagon on the splanchnic vascular bed.³ Glucagon exerts positive inotropic and chronotropic effects on the heart.^4,5 In dogs, a single injection of glucagon increased the cardiac output 36% and the coronary artery flow 54%.⁶ The greatest flow increase produced by glucagon (190%) was recorded in the superior mesenteric artery.⁷

The mechanism by which glucagon exerts its cardiovascular effects is not known. Originally, Shoemaker et al¹ suggested that the increase in hepatic blood flow could be a consequence of increased metabolic activity of the liver incident to rapid glycogenolysis. However, the action of glucagon on cardiac performance was as effective on the isolated . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

From the Department of Surgery, State University of New York, and the Surgical Research Laboratory, E. J. Meyer Memorial Hospital, Buffalo.

Footnotes
Accepted for publication Nov 12, 1969.

Reprint requests to Surgical Research Laboratory, E. J. Meyer Memorial Hospital, Buffalo 14215 (Dr. Schenk).

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