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A New Fluoroalkyl Cyanoacrylate Surgical Adhesive
Robert A. Nelson, DVM;
Eldon H. Banitt, PhD;
Donald C. Kvam, PhD;
J. Kenneth Harrington;
Jerry E. Robertson, PhD;
Joseph S. Buelow
AMA Arch Surg. 1970;100(3):295-298.
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Current methods for wound closure and control of hemorrhage, although used for years, leave much to be desired. This is particularly true in surgery involving highly vascular organs, glandular tissue, blood vessels, or the gastrointestinal tract. A safe and effective tissue adhesive would do much to eliminate the undesirable aspects of conventionally used wound repair methods. Over the past several years considerable interest has been focused on the alkyl-2-cyanoacrylates as possible tissue adhesives. However, these agents have disadvantages, not the least of which is the production of a high degree of tissue irritation at the site of application.1-6
In an attempt to develop improved tissue adhesives, a number of new fluoroalkyl cyanoacrylates were synthesized and evaluated in the laboratories of 3M Company. Of the compounds evaluated, β,β,β-trifluoro-isopropyl  -cyanoacrylate (MBR 4197) showed the best apparent combination of high bond strength and acceptable flexibility, relatively low tissue toxicity, and good handling
. . . [Full Text PDF of this Article]
Author Affiliations
St. Paul
From the 3M Company Biochemical Research Laboratory, St. Paul.
Footnotes
Accepted for publication Dec 8, 1969.
Read in part before the 52nd annual meeting of the Federation of American Societies for Experimental Biology, Atlantic City, NJ, April 20, 1968.
Reprint requests to 3M Company, Biochemical Research Laboratory, 3M Center, St. Paul 55101 (Dr. Nelson).
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