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Human Malignant Melanoma Antibodies Demonstrated by Immunofluorescence
Marvin M. Romsdahl, MD, PhD;
Irene Sebastian Cox, MA
AMA Arch Surg. 1970;100(4):491-497.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Immunological differences between tumors induced by either chemical carcinogens or viruses and the tissue from which such tumors originate have been demonstrated in almost all systems in which this feature was investigated.1,2 In addition, antigenic properties have been shown for spontaneous experimental tumors of various histological types.3 Antigens designated as a specific character of the neoplastic cells have been demonstrated by presensitization of an isologous host which then is relatively resistant to subsequent challenges with the transplanted tumor. This sensitization usually is achieved by excision of tumor after a short period of growth, irradiation of an established tumor, or injection of lethally irradiated tumor cells. The immunological basis for this resistance in chemically induced tumors has been found by demonstrating the in vitro activity of immune lymphocytes on tumor cells4,5 or by adoptive transfer of immunity to syngeneic animals. Serological tests for demonstrating antibody against these tumors
. . . [Full Text PDF of this Article]
Author Affiliations
Houston
From the Department of Surgery, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston.
Footnotes
Accepted for publication Dec 10, 1969.
Read before the 77th annual meeting of the Western Surgical Association, Nov 22, 1969.
Reprint requests to Department of Surgery, Univeristy of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77025 (Dr. Romsdahl).
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