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Preservation of the Anoxic Heart With a Metabolic Inhibitor and Hypothermia
Teiko M. Kamiyama, MD;
Watts R. Webb, MD;
Roger R. Ecker, MD
AMA Arch Surg. 1970;100(5):596-599.
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Previous studies demonstrated that refrigeration in a balanced electrolyte solution with 10% serum at 4 C for eight hours allowed dog hearts to return to relatively normal function after homotransplantation.1 Utilization of magnesium sulfate (MgSO4) as a metabolic inhibitor extended the tolerance of rat hearts to ischemia at normothermia from less than 15 minutes to four hours and of dog hearts from less than an hour to over three hours.2 A solution of magnesium, glucose, and dextran 40 maintained satisfactory viability of the lung in situ at normothermia for over four hours and at 4 C for over eight hours.3 The present study was designed to evaluate the preservative effects of combining a metabolic inhibitor and hypothermia for storage of isolated rat hearts up to 48 hours.
Materials and Methods
Albino rats averaging 250 gm in weight were anesthetized with ether and the hearts excised. The
. . . [Full Text PDF of this Article]
Author Affiliations
Dallas
From the Department of Surgery, University of Texas Southwestern Medical School, Dallas. Dr. Ecker is research associate at the Dallas Veterans Administration Hospital.
Footnotes
Accepted for publication Oct 21, 1969.
Read before the session on the cardiovascular system of the Ninth Multidiscipline Research Forum during the 118th annual convention of the American Medical Association, New York, July 15, 1969.
Reprint requests to Department of Surgery, State University of New York Upstate Medical Center, 750 E Adams St, Syracuse 13210 (Dr. Webb).
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