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Mechanism of Decreased Venous ReturnSubhuman Primate-Administered Endotoxin
Lerner B. Hinshaw, PhD;
Linda L. Shanbour, PhD;
Lazar J. Greenfield, MD;
Jacqueline J. Coalson, PhD
AMA Arch Surg. 1970;100(5):600-606.
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Recent work published by this laboratory in the subhuman primate has demonstrated that the primary cause of the decrease in mean systemic arterial pressure following a lethal injection of endotoxin is a decrease in venous return.1 However, a marked difference in response to endotoxin is observed in monkeys in contrast to dogs. In the former, a gradual fall in mean systemic arterial pressure is observed, and there is neither demonstrable pooling in the hepatosplanchnic bed nor loss of circulating blood to extravascular compartments.1-5
The cause of the decrease in venous return in the primate has not been determined. A previous study did not differentiate between a decrease in venous return due to peripheral pooling or failure of cardiac contractility.1 The cardiac output in some human patients shows a steady decline,6,7 although there is no evidence of primary cardiac failure in man6 or the nonhuman primate.
. . . [Full Text PDF of this Article]
Author Affiliations
Oklahoma City
From the Veterans Administration Hospital, and the departments of physiology (Drs. Hinshaw and Shanbour), medicine (Dr. Shanbour), pathology (Dr. Coalson), and surgery (Drs. Hinshaw and (Greenfield), University of Oklahoma Medical Center, Oklahoma City.
Footnotes
Accepted for publication Jan 13, 1970.
Reprint requests to Veterans Administration Hospital, 921 NE 13th St, Oklahoma City 73104 (Dr. Hinshaw).
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