This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (22)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Thomas C. Moore, MD; Dennis P. Thompson, MD; Michael Hayes, MD

AMA Arch Surg. 1970;101(1):45-51.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An inflammatory reaction forms a prominent part of the biochemical and physiological processes involved in the acute rejection of tissue and organ allografts. Significant increase in the size of the transplanted organ with edema and cellular infiltration is a constant feature of acute rejection. In most instances, this process is reversible through the administration of large amounts of corticosteroids. It is probable that a significant portion of the effect of corticosteroids on the reversal of acute allograft rejection is anti-inflammatory.

Unpublished as well as published evidence has been obtained in recent years by us and our associates,^1-10 suggesting an involvement of accelerated intracellular histamine formation and release in acute allograft rejection. An increase in intracellular histamine formation from histidine decarboxylase enzyme activity during allograft rejection has been found both at the site of allograft rejection and in distant immunologically involved lymphoid tissue.^7,8 Inhibitors of the histamine-forming enzyme have . . . [Full Text PDF of this Article]

Author Affiliations
Torrance, Calif

From the Surgical Research Laboratories and the surgical and radiological services, University of California (Los Angeles)-Harbor General Hospital, Torrance, Calif, and the departments of surgery and radiology, University of California School of Medicine, Los Angeles.

Footnotes
Accepted for publication March 9, 1970.

Read before the sectional meeting of the Southern California Chapter of the American College of Surgeons, Coronado, Calif, Jan 16, 1970.

Reprint requests to Surgical Research Laboratories, University of California (Los Angeles)-Harbor General Hospital, Torrance, Calif 90509 (Dr. Moore).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?