This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JACOB FINE, MD
Stanford, Calif

Arch Surg. 1975;110(7):848.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—In the December 1974 issue of the ARCHIVES (109:741), E. N. Wardle presents data that confirm previous reports showing a high correlation between the development of endotoxemia and the hemorrhagic complications of major injury to the liver. One can account for this effect of endotoxin by its capacity to aggregate platelets and, thus, release vasoactive agents that can cause the endotoxemia and become self-sustaining. Dr. Wardle refers to the report by Das et al that states that endotoxin binds to platelets by virtue of the fact that the larger fraction, if not all, of the circulating endotoxin is found in platelet-rich and not in platelet-poor plasma. Since we could not, in a joint study with Deykin (unpublished data), confirm the alleged binding of endotoxin to the platelets, it appears that the data of Das et al reflect the variation in particle size of circulating endotoxin. Thus, the . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?