INTRODUCTION
This experimental study was undertaken to determine the changes occurring in the different tissues of long bones following simple fracture which finally result in osseous union of the fragments.
By simple fracture is meant one in which there has been solution of continuity of the cortical bone without separation of the fragments, or with reposition of the fragments to as nearly the normal position as possible and with a minimum of damage to the soft parts, especially to the periosteum.
The observations include: (1) the immediate changes in the bone and the surrounding soft parts following fracture that resulted from trauma, and (2) the changes constituting the inflammatory reaction which result in the repair of the fracture.
A description of the gross specimens was noted, roentgenographic examination made and, finally, the specimens were studied microscopically.
The different tissues involved in the process of repair, viz., the cortical bone, the
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