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Nicolas V. Christou, MD; John A. Mannick, MD; Michael A. West, MD; Dennis L. Kasper, MD

Arch Surg. 1987;122(2):239-251.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTRODUCTION TO THE PROBLEM

The moderator for the discussion was Nicholas V. Christou, MD, from Montreal, and the panelists were John A. Mannick, MD, from Boston; Michael A. West, MD, from Minneapolis; and Dennis L. Kasper, MD, from Boston.

DR CHRISTOU: Research into host defenses against life-threatening infections following surgery and trauma has been extensive in the last ten years. Abnormalities in all components of host defense have been detected in both elective and emergency surgical patients. A curious finding is that anergy to delayed-type hypersensitivity skin test antigens will identify preoperative patients with a higher risk for septic related mortality.¹ This finding has been confirmed by many laboratories throughout the world^2-10 with the exception of the group from Britain.¹¹ This observation is curious because classic theory would have such patients develop opportunistic infections with viruses and intracellular parasites. This is not the case. Such patients develop gram-negative . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Surgery, Royal Victoria Hospital, Montreal (Dr Christou); the Department of Surgery (Dr Mannick) and the Channing Laboratory (Dr Kasper), Brigham and Women's Hospital, Boston; Harvard Medical School, Boston (Drs Mannick and Kasper); the Department of Surgery, University of Minnesota Hospital, Minneapolis (Dr West); and the Division of Infectious Diseases, Beth Israel Hospital, Boston (Dr Kasper).

Footnotes
Accepted for publication Oct 20, 1986.

Reprint requests to Department of Surgery, Royal Victoria Hospital, 6687 Pine Ave W, Montreal PQ H3A 1A1, Canada (Dr Christou).

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