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WITH SPECIAL REFERENCE TO DISEASE IN THE LOWER RIGHT QUADRANT AND TO THE MECHANISMS INVOLVED

MANUEL GRODINSKY, M.D.

Arch Surg. 1932;24(4):660-674.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

If whole blood to which some anticoagulant, such as sodium citrate, has been added is allowed to stand in a test tube, the erythrocytes (and leukocytes) will gradually settle, leaving a clear plasma above. That there is a marked variation in the settling time of blood in health and in inflammatory conditions has been noted by many observers. Galen spoke of the erythrocytes as forming a buffy coat or "crusta phlogista." In 1791, John Hunter noted that the erythrocytes of blood settled more quickly in inflammatory conditions than in normal blood, and that the red cells of normal blood, separated from their own plasma and transferred to the plasma of infected blood, settled with greater speed, the rate being in direct relation to the severity of the infection. This observation became the stimulus for numerous investigations and reports both in this county and abroad (Müller, 1844; Davy, 1839; Nasse, 1836, . . . [Full Text PDF of this Article]

Author Affiliations
OMAHA

From the Departments of Anatomy and Surgery, College of Medicine, University of Nebraska.

Footnotes
Submitted for publication, July 30, 1931.

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