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SELECTIVE STAINING OF DISEASED AREAS IN CARTILAGE BY INTRA-ARTICULAR INJECTION OF DYESAN EXPERIMENTAL CADAVER STUDY, WITH SPECIAL REFERENCE TO ARTHROSCOPY
MICHAEL S. BURMAN, M.D.
Arch Surg. 1933;26(1):153-159.
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The intra-articular injection of dyes is not a new procedure, though practiced only from the experimental standpoint to determine the absorptive capacity of the synovial membrane and the paths of absorption. A review of the literature indicates that no attention has been paid to the gross staining of cartilage by dyes. Tillmanns, in 1876, injected berlin blue into the bony canals of the amputated femurs of his experimental animals, after cutting away the bony plate that intervenes between the femur and the joint cavity. He intended to study the absorptive power of the synovia, without injuring either synovia or capsule. In seven cases, he noted a superficial staining of cartilage, easily washed out by a stream of water. Schreiber of Tübingen, in 1904, in analyzing the constituents of Belchier's madder, noted that purpurin, injected into the dorsal lymph sac of the frog, stained cartilage vitally a purple hue.
The gross
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Author Affiliations
NEW YORK
All the work on cadavers was done at the Pathological Institute of the Krankenhaus der Friedrichstadt-Dresden, through the kindness of Geheimrat Schmorl, during a period of time when I was Scholar of the Henry W. Frauenthal Traveling Scholarship. The animal work was done at the Hospital for Joint Diseases, New York, with the assistance of Dr. M. Langsam and through the kindness of Dr. Henry Jaffe.
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