This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

O. W. BARLOW, M.D.

Arch Surg. 1933;26(4):689-695.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Avertin (tribromethanol) was first introduced for clinical use as a crystalline preparation to be administered rectally as a 2.5 to 3 per cent solution in distilled water. The low solubility of the preparation in water (3.5 per cent at 40 C.) necessitates the rectal administration of relatively large volumes of fluid. At temperatures above 40 C. solutions of avertin decompose into hydrobromic acid and dibromacetaldehyde. Owing to these disadvantages, avertin fluid has largely displaced the aqueous solutions for clinical uses.

Avertin fluid contains in each cubic centimeter 1 Gm. of avertin crystals and 0.5 cc. (407.5 mg.) of tertiary amyl alcohol (amylene hydrate). This preparation is said to be more stable than the aqueous solutions of avertin, and the amylene hydrate has been reported to accelerate the rate of absorption of the solute from the rectum. In addition, since the solvent alone is somewhat hypnotic, the combination of avertin and . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Pharmacology of the School of Medicine of Western Reserve University.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?