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PRODUCED BY INTRA-ARTICULAR INJECTIONS OF BACTERIAL FILTRATES AND OTHER FOREIGN PROTEINS

ALEXANDER BRUNSCHWIG, M.D.; LUCY DELL HENRY, B.S.

Arch Surg. 1933;27(6):1065-1071.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In recent years the allergic hypothesis for the etiology of chronic arthritis, especially the proliferative type, has received considerable attention.¹ According to this theory, the articular changes are local manifestations of a generalized allergic state. As early as 1902, Menzer² suggested that streptococci first gained access to the joints, but that this did not result in inflammatory changes until antibodies were produced. Further researches by Weintraud,³ Henry,⁴ Faber,⁵ Friedberger,⁶ Freiberg,⁷ Klinge⁸ and Gudzent⁹ demonstrated that arthritic changes could be produced in experimental animals by first sensitizing the animal to bacterial or nonbacterial proteins and then by injecting the antigen into the joints. Similar results were obtained if the antigen was injected first into the joint and later into the general circulation. Swift¹⁰ and his coworkers have recently studied experimental streptococcus allergy in rabbits, with the view of explaining the etiology . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery of the University of Chicago.

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