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II. GROWTH OF ORGANISMS IN BLOOD RENDERED INCOAGULABLE WITH HIRUDIN AND HEPARIN

HOWARD R. MAHORNER, M.D.; ALTON OCHSNER, M.D.

Arch Surg. 1935;31(3):371-374.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In another paper,¹ we reported the effects of the application of leeches and of the intravenous injection of hirudin and heparin on bacteremia induced in dogs by the intravenous injection of a suspension of staphylococci. We became interested in this investigation because of the good results we obtained with leeches in the treatment of phlebitis and because of the report by Bosc and Delezenne² in which the authors stated that animals are protected from bacteremia by the intravenous injection of hirudin and that in vitro there is an inhibition of the growth of organisms in blood to which hirudin has been added. We conducted both in vivo experiments (on dogs) and in vitro experiments to determine if we could demonstrate such an effect of hirudin on the growth of organisms in blood. Our in vitro experiments are reported in this paper.

EXPERIMENTS

Experiment 1.

—Nine sterile test tubes . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Department of Surgery, Tulane University School of Medicine.

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