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RATE OF FIBROPLASIA AND DIFFERENTIATION IN THE HEALING OF CUTANEOUS WOUNDS IN DIFFERENT SPECIES OF ANIMALS
EDWARD L. HOWES, M.D.;
SAMUEL C. HARVEY, M.D.;
CORNELIA HEWITT, B.A.
Arch Surg. 1939;38(5):934-945.
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In the healing of wounds of muscle, fascia, skin and gastric wall of the dog, strength returns in a definite manner. During the first four days, the wounds have only the strength contributed by the sutures and the adhesion of the wound surfaces; subsequently, however, strength mounts rapidly, reaching a maximum on the twelfth to the fourteenth day of healing.1 This increase in strength is accompanied microscopically by regeneration of fibrous tissue; hence, strength is used as an index to the rate of fibroplasia. Because the rate of fibroplasia is the same in the healing of these diversified anatomic structures, it has occurred to us that the rate should be studied in the healing of wounds of one tissue in several species of animals. In this way any influence on the rate of fibroplasia due to differences in species could be determined. In the experiments described here, therefore, the
. . . [Full Text PDF of this Article]
Author Affiliations
WASHINGTON, D. C.; NEW HAVEN, CONN.
From the Department of Surgery, the Yale University School of Medicine.
Footnotes
Financial aid for this investigation was furnished by the National Research Council.
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