This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

GORDON MURRAY, M.B., F.R.C.S. (Eng. & Can.)

Arch Surg. 1940;40(2):307-325.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The valiant efforts made by many investigators to advance the treatment of diseases and injuries of blood vessels have been hampered by thrombosis and clotting in these structures. The uncontrollable factor leading to failure in many cases is not the giving way or leaking of suture lines or weakness, dilatation or stenosis of blood vessels but is occlusion of the vessels by thrombosis. The discovery of the anticoagulant heparin by Howell¹ in 1916 was therefore an epoch-making event. More recently, experiments by Murray and his co-workers² demonstrating that heparin would also prevent thrombosis were of importance in developing this subject. The final purification of heparin by Best and by Charles and Scott³ made it safe to give this substance to clinical patients.

EXPERIMENTAL DATA

Heparin is a strong organic acid, probably a mucoitin trisulfuric acid. In addition to preventing clotting, it has an important effect on the . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO, CANADA

From the Toronto General Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?