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J. GARROTT ALLEN, M.D.; ORMAND C. JULIAN, M.D.

Arch Surg. 1940;40(5):912-916.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1939, McKee and Doisy and their co-workers¹ showed that vitamin K has a quinoid structure. This led to investigation of the antihemorrhagic value in cases of experimental hypoprothrombinemia of many of the quinones. Of those examined, the 2-methyl-1,4-naphtho-quinone and the 2-methyl-3-hydroxy-1,4-naphthoquinone possessed the greatest antihemorrhagic activity.² Rhoads and Fliegelman³ have recently reported favorable results in the control of hypoprothrombinemia in the human patient by the use of 2-methyl-1,4-naphtho-quinone. Binkley, Doisy and others⁴ and Feiser⁵ have recently shown that 2-methyl-3-phytyl-1,4-naphthoquinone and the natural vitamin K possess identical physical properties and the same empiric formula.

PRESENTATION OF DATA

In this paper are presented 10 cases of clinical hypoprothrombinemia of various causes and the responses of the patients to administration of 2-methyl-1,4-naphthoquinone. These cases are summarized in the accompanying table. Daily studies of the plasma prothrombin were made for each patient while he was receiving the drug. . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery of the University of Chicago.

Footnotes
This work has been aided by grants from the Douglas Smith Foundation for Medical Research of the University of Chicago.

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