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FREDERICK M. ALLEN, M.D.

Arch Surg. 1940;41(1):79-90.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been shown elsewhere¹ that temporary asphyxia produced by local ligation damages tumors selectively, in such a manner as to cause extensive and sometimes complete necrosis of the tumor while the normal tissues are unharmed except for transitory inflammation. These results (with transplanted tumors of rats and mice) were substantially duplicated with the chicken sarcoma,² which is composed of autogenous cells, but the persistence of the chemical excitant was assumed to be responsible for the trivial number of actual cures in proportion to recurrences and deaths. It was obviously desirable to extend the trials of asphyxia to tumors native to the mammalian body. Circumstances unfortunately did not warrant undertaking the chemical production of tumors with tar derivatives. A number of rat and mouse tumors were obtained by special arrangements with large dealers.

1. RAT FIBROMA

This is a common benign growth which develops slowly to huge size, . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

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