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USE OF THE SUBSTANCE IN TREATMENT OF CONGENITAL AND SIMPLE COLLOID GOITER

WILLIAM FRANCIS RIENHOFF, Jr., M.D.

Arch Surg. 1940;41(2):487-507.

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The first demonstration of the effect of a substance from outside the body on the microscopic structure of the thyroid gland was the deposition of colloid within the follicles of the thyroid gland of the dog after the administration of iodine, reported by des Ligneris¹ in 1907 and by Marine and his co-workers² in 1908. Since these early observations there have appeared in the literature from time to time controversial reports regarding the effects of iodine and other substances on the normal thyroid as well as on certain types of enlargement of the gland, (Loeb³ and others^3a). It would be aside from the purpose of this paper to attempt a critical résumé of the vast literature on this subject up to the present, for, although there have been many and important contributions to knowledge of enlargement of the thyroid gland, the cause and method of prevention . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Surgery, Johns Hopkins University.

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