This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. GARROTT ALLEN, M.D.; ORMAND C. JULIAN, M.D.; LESTER R. DRAGSTEDT, M.D.

Arch Surg. 1940;41(4):873-878.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent advances in the study of blood coagulation have been stimulated by the discovery of vitamin K and its relation to prothrombin. While there is considerable variance of opinion as to the nature of blood coagulation, it can be assumed that at least five factors are necessary before this phenomenon occurs. These include ionizable calcium, thromboplastin, prothrombin, thrombin and fibrinogen. It is generally agreed that these substances act in the following manner, as was suggested by Howell¹ in 1914.

Based on this theory of coagulation, several methods for the measurement of prothrombin have been devised. Of these, the two stage method of Warner, Brinkhous and Smith² and the one stage method of Quick³ have been more frequently employed than the others.

The two stage technic of Warner, Brinkhous and Smith is carried out as follows: Oxalated plasma is defibrinated by the addition of purified thrombin.² This . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery of the University of Chicago.

Footnotes
This work has been aided by a grant from the Douglas Smith Foundation for Medical Research of the University of Chicago.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?